Endocrine pancreatic control of the release of gastric inhibitory polypeptide

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Pancreatic and Extrapancreatic Effects of Gastric Inhibitory Polypeptide

The hormonal factor(s) implicated as transmitters of signals from the gut to pancreatic -cells is referred to as incretin, and gastric inhibitory polypeptide (GIP) is identified as one of the incretins. GIP is a gastrointestinal peptide hormone of 42 amino acids that is released from duodenal endocrine K-cells after absorption of glucose or fat and exerts its effects by binding to its specific ...

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Gastric inhibitory polypeptide (GIP).

As long ago as 1930, Kosaka and Lim proposed a humoral agent capable of inhibiting gastric acid secretion after a meal. They coined the term enterogastrone. Using crude preparations of cholecystokinin-pancreozymin (CCK PZ) in dogs they were able to inhibit the acid secretion normally stimulated by a meat meal or histamine. They went on to experiment with duodenal extracts, prepared after the in...

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Gastric Inhibitory Polypeptide in the Brain

The hippocampus is an area of active cell proliferation and neurogenesis within the adult mammalian brain. Adult neurogenesis is of great importance for the brain, since it increases neuroplasticity and the ability to respond to environmental stimuli. It also provides a possible mechanism for the brain to replace lost cells that have died due to injury or disease. However, the molecular events ...

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Distribution and release of human pancreatic polypeptide.

A simple and reliable radioimmunoassay has been developed for a new gut hormone, HPP. In the primate 93% of the total PP was found in the pancreas with a small amount throughout the remaining gastrointestinal tract. HPP has been shown to be produced by a number of pancreatic apudomas and their metastases. The immunoreactive PP from these tumours and from normal pancreas was chromatographically ...

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ژورنال

عنوان ژورنال: Diabetologia

سال: 1980

ISSN: 0012-186X,1432-0428

DOI: 10.1007/bf00280527